The cause of Churg-Strauss syndrome is largely unknown.

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Churg-Strauss syndrome and It’s likely that a combination of genes and environmental factors, such as allergens or certain medications, triggers an overactive immune system response. Instead of protecting against invading bacteria and viruses, the immune system targets healthy tissue, causing widespread inflammation.

Risk factors

Possible risk factors for Churg-Strauss syndrom include:

  • Age. On average, people with Churg-Strauss syndrom are diagnosed between 30 and 50 years of age.
  • History of asthma or nasal problems. Most people diagnosed with Churg-Strauss syndrom have a history of severe nasal allergies, chronic sinusitis or asthma.

Complications

Churg-Strauss syndrome can affect many organs, including your lungs, skin, gastrointestinal system, kidneys, muscles, joints and heart. Without treatment, the disease can be fatal.

Complications, which depend on the organs involved, can include:

  • Peripheral nerve damage. Churg-Strauss syndrome can damage the nerves in your hands and feet, leading to numbness, burning and loss of function.
  • Skin scarring. The inflammation can cause sores that can leave scars.
  • Heart disease. Heart-related complications of Churg-Strauss syndrome include inflammation of the membrane surrounding your heart, inflammation of the muscular layer of your heart wall, heart attack and heart failure.
  • Kidney damage. If Churg-Strauss syndrome affects your kidneys, you can develop glomerulonephritis. This disease hampers your kidneys’ filtering ability, leading to a buildup of waste products in your bloodstream.

 

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